Non-Opioid Treatment for Diabetic Neuropathy
If you want to manage painful diabetic neuropathy without opioids, the NS100 by NeuroDynamics Global is an FDA-cleared, non-pharmacologic 20-day neuromodulation therapy. It targets nerve pain directly, with no opioids, no daily pills, and no permanent implant.
Why a non-opioid option matters in PDN
Painful diabetic neuropathy is one of the most common reasons people with diabetes are prescribed opioids. The CDC and major pain societies recommend non-opioid options first whenever possible, both because of the risks of long-term opioid use and because opioids are often only modestly effective for nerve pain.
Non-opioid alternatives historically include gabapentin, pregabalin, duloxetine, capsaicin, lidocaine patches, and TENS. These help some patients but leave many with inadequate relief, side effects, or both.
Neuromodulation is a non-opioid, non-pharmacologic option that targets the nerve activity producing the pain — not the brain's perception of it. NS100 brings this approach in a temporary, 20-day form.
Key facts
- Non-opioid — no controlled substance prescription
- Non-pharmacologic — no daily pills or systemic side effects
- Temporary — 20-day therapy, not a permanent implant
- FDA-cleared Class II medical device
- Covered by Medicare for eligible patients
- Can be used alongside existing diabetes management
Why it matters
Avoids opioid risk
No risk of opioid dependence, no DEA controls, no constipation or sedation associated with opioid analgesics.
Targets nerves directly
Stimulation is delivered at the peripheral nerve target, not absorbed systemically through the bloodstream.
Defined endpoint
20-day course with a clear start and finish — not an indefinite prescription you have to keep refilling.
FDA-cleared
Class II clearance for chronic pain associated with painful diabetic neuropathy.
How NS100 fits into a non-opioid pain plan
NS100 can be the primary therapy for patients who have not gotten relief from first-line non-opioid medications, or who want to come off opioids without losing pain control. It is delivered in a single 20-day course rather than a continuous prescription — which means a defined endpoint, a clear evaluation window, and no medication to taper.
Because NS100 is non-pharmacologic, it can be used alongside your existing diabetes management without drug-drug interactions or systemic side effects. Your prescribing physician will continue to manage glucose control, statins, blood pressure, and any other ongoing therapies in parallel.
What to ask your provider
If you are interested in a non-opioid path, ask your provider whether you are a candidate for peripheral nerve stimulation, whether your insurance (including Medicare) covers it, and what to expect during and after the 20-day protocol. Our team can help your provider with reimbursement and scheduling logistics.
Frequently asked questions
Ready to learn if NS100 is right for you?
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